Table 1.
Patient | Infectious Diagnosis | Pathogen | Susceptible to C/T? | Antibiotic Allergies | Dose/Day (Grams) | Duration (Days) | Satisfaction Score (avg) |
---|---|---|---|---|---|---|---|
1a,b | cUTI | MDR Pseudomonas aeruginosa | Susceptible (25-mm zone diameter) | PCN | 4.5 | 14 | N/A |
2a | Pneumonia | P aeruginosa | Not tested | None | 4.5 | 17 | N/A |
3a | Pneumonia | P aeruginosa | Not tested | None | 9 | 6 | N/A |
4 | Discitis | P aeruginosa | Not tested | PCN | 4.5 | 42 | N/A |
5a,b | cUTI | MDR P aeruginosa | Intermediate (Etest MIC = 8/4 mcg/mL) | Erythromycin | 4.5 | 7 | 4 |
6a,b | Bacteremia | P aeruginosa Escherichia coli | Not tested | PCN, Sulfa | 4.5 | 10 | 4.2 |
7a | Pneumonia | MDR P aeruginosa | Susceptible (Etest MIC 2/4 mcg/mL) | Doxycycline | 4.5 | 14 | 5 |
Abbreviations: avg, average; CI, continuous infusion; C/T, ceftolozane/tazobactam; cUTI, complicated urinary tract infection; MDR, multidrug-resistant; MIC, minimum inhibitory concentration; N/A, not applicable; PCN, penicillin.
aClinical cure (6 of 7 patients).
bMicrobiological cure (3 of 3 patients).