Table 2.
Pharmacokinetic parameter valuesa (weighted by support point probability) for the final iohexol model (n = 176)
| Parameters | Mean | Median | 95% CI | Shrinkage (%) |
|---|---|---|---|---|
| CLs (L/h) | 2.60 | 1.55 | 2.22–2.97 | 0.8 |
| Qs (L/h) | 9.44 | 5.99 | 8.03–11.42 | 4.0 |
| Vs (L) | 10.96 | 10.47 | 10.25–11.68 | 4.1 |
| Vps (L) | 9.44 | 8.02 | 8.66–10.23 | 7.3 |
CI, confidence interval; CLs, clearance; Qs, intercompartment clearance; Vps, peripheral volume of distribution; Vs, central volume of distribution.
a
Slope values are presented. To obtain individual values, CLs and Qs should be multiplied by (actual patient weight [kg]/85 [kg])0.75 and Vs and Vps by (actual patient weight [kg]/85 [kg])1.00. Shrinkage is obtained from the approximations integrated in Pmetrics package for R.