Figure 7.
Measures of Mitochondrial Function
(Left) Bar graphs depicting total cardiolipin level (CL) normalized to mitochondrial (MITO) protein (top), total (18:2)4 CL normalized to MITO protein level (middle), and MITO complex IV activity (bottom) in left ventricular myocardium of NL dogs, untreated HF control dogs (HF-CON), and dogs with HF treated with elamipretide (HF+ELA). (Right) MITO states 3 and 4 respiration (top), MITO membrane potential (middle), and maximum rate of ATP synthesis (bottom) in left ventricular myocardium of NL dogs, untreated HF-CON dogs, and HF+ELA dogs. All bar graphs are depicted as mean ± SEM.
Adapted with permission from Sabbah et al. (57). ADP = adenosine diphosphate; RLU = relative light units.