Figure 2.

The domain repertoire. A total of 274 protein domains were identified from ORFs encoded by genomes of members of the Herpesviridae family. In this circular map, viral species are positioned following the same vertical order as shown in Fig. 1, with heatmaps of distinct subfamilies clearly separated. Domains with similar function were grouped, and the horizontal order of domains (clockwise sense) was defined based on their absolute frequency (i.e. most conserved domains are shown at the first columns of each group). Please observe that the lightest color shade of each group indicates domains that are absent in some species. As observed, only a small set of domains (n = 28, see arrowheads) was found across all species, and most domains (n = 203) are restricted to a single subfamily. Supplementary Table S1 presents a matrix of domains counts per viral species. The circular map was designed using Circos (Krzywinski et al. 2009).