Table 1.
Minimal set of forty-one domains encoded by the MRCA of Herpesviridae.
| Domain | Gene | Absolute frequency | Distribution | Function |
|---|---|---|---|---|
| PF01771 (Herpes_alk_exo) | UL12 | 75 | α + β + γ | Auxiliary |
| PF01712 (dNK) | – | 26 | α + β + γ | Auxiliary |
| PF02499 (DNA_pack_C) | UL15 | 75 | α + β + γ | Capsid assembly and structure |
| PF02500 (DNA_pack_N) | UL15 | 75 | α + β + γ | Capsid assembly and structure |
| PF04559 (Herpes_UL17) | UL17 | 75 | α + β + γ | Capsid assembly and structure |
| PF01802 (Herpes_V23) | UL18 | 75 | α + β + γ | Capsid assembly and structure |
| PF03122 (Herpes_MCP) | UL19 | 75 | α + β + γ | Capsid assembly and structure |
| PF01499 (Herpes_UL25) | UL25 | 75 | α + β + γ | Capsid assembly and structure |
| PF00716 (Peptidase_S21) | UL26.5 | 75 | α + β + γ | Capsid assembly and structure |
| PF01366 (PRTP) | UL28 | 75 | α + β + γ | Capsid assembly and structure |
| PF02718 (Herpes_UL31) | UL31 | 75 | α + β + γ | Capsid assembly and structure |
| PF01673 (Herpes_env) | UL32 | 75 | α + β + γ | Capsid assembly and structure |
| PF03581 (Herpes_UL33) | UL33 | 75 | α + β + γ | Capsid assembly and structure |
| PF03327 (Herpes_VP19C) | UL38 | 75 | α + β + γ | Capsid assembly and structure |
| PF01763 (Herpes_UL6) | UL6 | 75 | α + β + γ | Capsid assembly and structure |
| PF04541 (Herpes_U34) | UL34 | 73 | α + β + γ | Capsid assembly and structure |
| PF03167 (UDG) | UL2 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00747 (Viral_DNA_bp) | UL29 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00136 (DNA_pol_B) | UL30 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF03104 (DNA_pol_B_exo1) | UL30 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF02689 (Herpes_Helicase) | UL5 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF03121 (Herpes_UL52) | UL52 | 75 | α + β + γ | DNA Replication, recombination and metabolism |
| PF02867 (Ribonuc_red_lgC) | UL39 | 73 | α + β + γ | DNA Replication, recombination and metabolism |
| PF03324 (Herpes_HEPA) | UL8 | 73 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00692 (dUTPase) | UL50 | 69 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00693 (Herpes_TK) | UL23 | 56 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00268 (Ribonuc_red_sm) | UL40 | 55 | α + β + γ | DNA Replication, recombination and metabolism |
| PF00317 (Ribonuc_red_lgN) | UL39 | 52 | α + γ | DNA Replication, recombination and metabolism |
| PF02399 (Herpes_ori_bp) | UL9 | 42 | α + β | DNA Replication, recombination and metabolism |
| PF01528 (Herpes_glycop) | UL10 | 75 | α + β + γ | Envelope |
| PF17488 (Herpes_glycoH_C) | UL22 | 75 | α + β + γ | Envelope |
| PF00606 (Glycoprotein_B) | UL27 | 75 | α + β + γ | Envelope |
| PF17416 (Glycoprot_B_PH1) | UL27 | 75 | α + β + γ | Envelope |
| PF17417 (Glycoprot_B_PH2) | UL27 | 75 | α + β + γ | Envelope |
| PF02489 (Herpes_glycop_H) | UL22 | 72 | α + β + γ | Envelope |
| PF03554 (Herpes_UL73) | – | 62 | α + β + γ | Envelope |
| PF05459 (Herpes_UL69) | UL54 | 75 | α + β + γ | Modulation and Control |
| PF01646 (Herpes_UL24) | UL24 | 75 | α + β + γ | Tegument |
| PF04843 (Herpes_teg_N) | UL36 | 75 | α + β + γ | Tegument |
| PF03044 (Herpes_UL16) | UL16 | 74 | α + β + γ | Tegument |
| PF01677 (Herpes_UL7) | UL7 | 72 | α + β + γ | Tegument |
The domains are shown with their absolute frequency among the fully sequenced genomes of members of the Herpesviridae family (75 = shared by all viruses), their distribution among the three subfamilies (α, β, and γ), and their functional categories. Genes are named as found in the HHV1 genome annotation.
–, genes with no homologs in HHV1.