TABLE 3.
Clinical trials using checkpoint inhibitors in HIV-infected populations
| Trial | Study drug | Target(s) | Population | Phase |
|---|---|---|---|---|
| NCT03787095 | Cemiplimab | PD1 | Suppressed HIV on ART | 1/2 |
| NCT03239899 | Pembrolizumab | PD-1 | CNS HIV reservoir | 1 |
| NCT03367754 | Pembrolizumab | PD-1 | HIV with low CD4+ cell count | 1 |
| NCT02595866 | Pembrolizumab | PD-1 | HIV and malignant neoplasms | 1 |
| NCT03304093 | Nivolumab | PD-1 | HIV and non-small-cell lung cancer | 2 |
| NCT02408861 | Nivolumab and ipilimumab | PD-1, CTLA-4 | HIV and malignant neoplasms | 1 |
| NCT03316274 | Nivolumab | PD-1 | HIV and Kaposi sarcoma | 1 |
| NCT03407105 | Ipilimumab | CTLA-4 | HIV | 1 |
| NCT03094286 | Durvalumab | PD-L1 | HIV and solid tumors | 2 |