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. 2020 Jan 17;94(3):e00375-19. doi: 10.1128/JVI.00375-19

TABLE 3.

Clinical trials using checkpoint inhibitors in HIV-infected populations

Trial Study drug Target(s) Population Phase
NCT03787095 Cemiplimab PD1 Suppressed HIV on ART 1/2
NCT03239899 Pembrolizumab PD-1 CNS HIV reservoir 1
NCT03367754 Pembrolizumab PD-1 HIV with low CD4+ cell count 1
NCT02595866 Pembrolizumab PD-1 HIV and malignant neoplasms 1
NCT03304093 Nivolumab PD-1 HIV and non-small-cell lung cancer 2
NCT02408861 Nivolumab and ipilimumab PD-1, CTLA-4 HIV and malignant neoplasms 1
NCT03316274 Nivolumab PD-1 HIV and Kaposi sarcoma 1
NCT03407105 Ipilimumab CTLA-4 HIV 1
NCT03094286 Durvalumab PD-L1 HIV and solid tumors 2