FIG 3.

Transcription profiles of three HSV-1 genes during the course of latency establishment and reactivation. (A) Schematic of a human DRG cell line-derived neuronal system used to investigate HSV-1 latency establishment, latency maintenance, and reactivation, as well as the related time point for sodium current recording. (B) The transcription of three viral genes (ICP0, TK, and LAT) was assessed by qRT-PCR at different time points (3 dpi, 7 dpi, and 12 dpi) in the absence of viral replication and was compared to those for lytic infection at 3 dpi and reactivation by TSA at 14 dpi. Asterisks indicate statistically significant differences (P < 0.05) from the corresponding gene in the 3-dpi no-ACV group (*) or the 12-dpi latency group (**). NS, not statistically significant.