TABLE 4.
Spatial location of putative adaptive mutations in NS3 protein
| Mutant | Residue change in conserved regions (aa position in polyprotein)a | Residue change in nonconserved regions (aa position in polyprotein)b | Location |
|---|---|---|---|
| Mutanth | F238L (1268) | D1 domain | |
| I286T (1316) | D1 domain | ||
| D290G (1320) | D1 domain | ||
| K373R (1403 | RNA entry site | ||
| D396G (1426) | RNA entry site | ||
| V567A (1597) | D3 domain | ||
| I17T (1047) | D1 domain | ||
| D25N (1055) | Protease domain | ||
| D296G (1326) | Protease domain | ||
| Mutantm | C292Y (1322) | D1 domain | |
| I426T (1456) | D2 domain | ||
| S188G (1218) | D1-D3 connecting region | ||
| V295A (1325) | D1-D3 connecting region | ||
| T505A (1535) | D3 domain | ||
| R514G (1544) | D1-D3 connecting region | ||
| Mutantl | A78T (1108) | Protease domain | |
| K122R (1152) | Protease domain | ||
| C289R (1319) | D1 domain | ||
| V511A (1541) | D1-D3 connecting region |