TABLE 3.

Summary of main features of ZIKV infection in MAb-treated CC strains and 129-Ifnar1 mice^a

Mouse strain	Symptoms	Mortality (%)	Peak plasma viral load	Rate of decrease of plasma viral load	Systemic infection		Intracerebral infection		Viral replication in vitro (24–72 h)
					Brain viral load	Brain pathology	Brain viral load	Brain pathology
CC001	−	0	+	Moderate	+	−	+	++	Decreasing
CC005	−	0	+++	Fast	+++	+++	+++	+++	ND
CC071	+++	78	+++	Moderate	+++	++	+++	++++	Increasing
129-Ifnar	++	12.50	+++	Fast	+++	+++	+++	++++	ND

^a−, absent; +, ++, +++, and ++++, present at increasing levels; ND, not done.