FIG 8.

Model for the suppression of RNAi in mammalian and mosquito cells by SFV capsid protein. When SFV entry the host cells, the single-stranded genomic (+)RNAs are used as templates to produce the negative genomic (–)RNAs. The (–)RNAs can be used as templates to produce more progeny (+)RNAs and subgenomic RNAs. The vRI-dsRNAs formed by the 5′-terminal nascent (+)RNAs or/subgenomic RNAs and the (–)RNA template could be recognized and cleaved by Dicer, thus triggering antiviral RNAi. SFV capsid protein can suppress antiviral RNAi by sequestrating dsRNA and siRNA as indicated.