FIG 6.

LINC00313-regulated cell movement-related genes in HMEC1 cells. (A) Summary of RNA-seq data. Total RNA extracted from HMEC1 cells treated as described in the legend to Fig. 5B were subjected to RNA-seq. Paired-end reads were aligned and annotated as described in the legend to Fig. 1A. RPKM higher than 0.05 in at least one sample were considered expressed and used for subsequent analysis. (B) Pie chart of mRNA expression data from LINC00313-overexpressing HMEC1 cells treated as described for panel A. The numbers (percentages) of mRNAs up- or downregulated more than 1.5-fold are shown. (C) Venn diagrams of differentially expressed mRNAs identified in LINC00313-overexpressing treatment (red) and in LINC00313-overexpressing-plus-HIV Tat treatment using overexpression cells as the Ctrl (blue).