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. 2019 Nov 13;28(2):367–381. doi: 10.1016/j.ymthe.2019.11.005

Figure 8.

Figure 8

Summary of Capsid Variant Entry Factor Requirements and Model

(A) Three different entry pathway classes exist in which capsids require both AAVR and GPR108 (red), AAVR only (blue), or GPR108 only (green). (B) Green capsids use an as-of-yet unidentified receptor or receptor complex in place of AAVR, dictated by the VP3 outer surface of intact capsids, while blue and red capsids both require AAVR (purple). (C) Blue capsids use an as-of-yet unidentified entry factor in place of GPR108, dictated by the internalized VP1-unique N terminus of capsid, while red and green capsids require GPR108 (brown).