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. 2019 Nov 18;28(2):490–502. doi: 10.1016/j.ymthe.2019.11.013

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Effect of Klotho-Carrying EVs and Recombinant Klotho

(A) Creatinine and BUN levels and number of tubular hyaline casts and tubular necrosis in AKI mice treated with saline (vehicle), uEVs, HK2 EVs (n = 6), and recombinant Klotho (rhKL) (n = 4) at day 3 after damage. Data are expressed as mean ± SEM; ANOVA with Dunnett’s multicomparison test was performed: *p < 0.05 or **p < 0.001 versus vehicle. (B) Representative micrographs of H&E of renal tissue from AKI mice treated with vehicle, uEVs, HK2 EVs, and recombinant Klotho (rhKL) at day 3 after damage. Original magnification ×200.