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. Author manuscript; available in PMC: 2020 Feb 5.
Published in final edited form as: Org Lett. 2017 Aug 31;19(18):4980–4983. doi: 10.1021/acs.orglett.7b02476

Table 2.

Optimization of the Acetylide Addition to 12

graphic file with name nihms-1552159-t0005.jpg
no.  X   promoter yield of 13 (%)
1 Li — 60a
2 MgBr — 65
3 MgCl ZnCl2 (10 mol %) 88a
4 MgCl — 97b
a

NMR yield.

b

13 was isolated as a 10:1 mixture of diastereomers.