REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD4-PerCpCy5.5 Clone GK1.5 (1:800)	Biolegend	#100434
CD4-ApcCy7 Clone GK1.5 (1:500)	Biolegend	#100413
CD4-BV711 Clone RM4-5 (1:1000)	Biolegend	#100594
CD8-PerCpCy5.5 Clone 53-6.7 (1:400)	Biolegend	#100734
CD25-AF700 Clone PC61 (1:400)	Biolegend	#102024
CD25-BV421 Clone PC61 (1:1000)	Biolegend	#102034
CD25-BV711 Clone PC61 (1:800)	Biolegend	#740714
CD44-PeCy7 Clone IM7 (1:400)	Biolegend	#103030
CD45.1-PE Clone A20 (1:200)	Biolegend	#110708
CD45.2-FITC Clone 104 (1:200)	Biolegend	#109806
CD62L-Pacific Blue Clone MEL-14 (1:200)	Biolegend	#104424
Foxp3-eF450 Clone FJK-16S (1:100)	eBioscience	#48-5773-82
ICOS-BV785 Clone C398.4A (1:400)	Biolegend	#313534
IFNγ-FITC Clone XMG1.2 (1:200)	Biolegend	#505806
IL-10 Purified Clone JES5-16E3 (1:100)	Biolegend	#505001
TNFα-PE Clone MP6-XT22 (1:200)	Biolegend	#506306
β-actin (1:10,000)	CST	4970S
FABP5 (D1A7T) Rabbit mAb (1:2000)	CST	#3326
Total OXPHOS Rodent WB Antibody Cocktail (1:2000)	Abcam	Ab110413
Stat1 (D1K9Y) Rabbit mAb (1:2000)	CST	#14994
Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (1:5000)	CST	#9167
InVivoMab anti-mouse CD3 (5 μg/mL)	BioXCell	BP0001-1
InVivioMab anti-mouse CD28 (0.5 μg/mL)	BioXCell	BE0015-1
InVivoMab anti-mouse IL-12p40 (10 μg/mL)	BioXCell	BE0051
InVivoMab anti-mouse IL-4 (10 μg/mL)	BioXCell	BE0199
InVivoMab anti-mouse IFN-γ (10 μg/mL)	BioXCell	BE0055
Biological Samples
Healthy Control Blood	UniKlinik Freiburg	N/A
Chemicals, Peptides, and Recombinant Proteins
BMS309403	Cayman Chemical	#10010206
C16-BODIPY	Thermo Fisher	D3821
Cell Trace Violet	Thermo Fisher	C34557
DMXAA	Sigma	D5817
Mitotracker Deep Red	Thermo Fisher	M22426
Live Dead Fixable Blue	Thermo Fisher	L23105
IFNα	PBL Assay Science	#12100-1
Recombinant murine IL-1β	Peprotech	211-11B-50
Recombinant human IL-2	Peprotech	200-02-1000
Recombinant mouse IL-4	Peprotech	214-14-100
Recombinant mouse IL-6	Peprotech	216-16-50
Recombinant mouse IL-7	Peprotech	217-17-50
Recombinant mouse IL-12	Peprotech	210-12-50
Recombinant mouse IL-15	Peprotech	210-15-15
Recombinant human TGFβ	Peprotech	100-21-50
Oligomycin	Sigma	#1404-19-9
FCCP	Sigma	#370-86-5
Rotenone	Sigma	#83-79-4
Antimycin A	Sigma	#1397-94-0
Critical Commercial Assays
Seahorse Extracellular Flux Analyzer XFe 96	Agilent	www.agilent.com
Deposited Data
GEO Submission (GSE126245)		https://www.ncbi.nlm.nih.gov/geo/
Experimental Models: Cell Lines
E.G7-OVA	ATCC	ATCC Cat# CRL-2113, RRID: CVCL_3505
Oligonucleotides
siRNA for murine cGAS	GE Dharmacon	#E-055608-00-0005
siRNA for murine STING	GE Dharmacon	#E-055528-00-0005
mtCytb FW (TTCATGTCGGACGAGGCTTA)	Sigma	N/A
mCytb RV (GTTTATTGGGGATTGAGCGTAG)	Sigma	N/A
mtND1 FW (CTAGCAGAAACAAACCGGGC)	Sigma	N/A
mtND1 RV (GTATGGTGGTACTCCCGCTG)	Sigma	N/A
mtND4 FW (ACAACACACACCTTAGACGCT)	Sigma	N/A
mtND4 RV (TGTGGATCCGTTCGTAGTTGG)	Sigma	N/A
Taqman 18 s Ribosomal RNA	Thermo Fisher	Mm03928990
Taqman Fabp3	Thermo Fisher	Mm02342495
Taqman Fabp4	Thermo Fisher	Mm00445878
Taqman Fabp5	Thermo Fisher	Mm00783731
Taqman Il10	Thermo Fisher	Mm01288386
Taqman Isg15	Thermo Fisher	Mm01705338
Taqman Ifi44	Thermo Fisher	Mm00505670
Taqman Rsad2	Thermo Fisher	Mm00491265
Taqman Ifna4	Thermo Fisher	Mm00833969
Taqman Acaa2	Thermo Fisher	Mm00624282
Taqman Elovl6	Thermo Fisher	Mm00851223
Taqman Fads1	Thermo Fisher	Mm00507605
Taqman Fads2	Thermo Fisher	Mm00517221
Taqman Scd1	Thermo Fisher	Mm00772290
Taqman Scd2	Thermo Fisher	Mm01208542
Software and Algorithms
Wave Software Version 2.4	Agilent	www.aglient.com
FlowJo v10	FlowJo	www.flowjo.com
GraphPad Prism 6	GraphPad Software	www.graphpad.com