Ariano 2001.

Methods	Randomised DBPC trial
Participants	Adults 10 active (5 m) 10 placebo (4 m)
Interventions	8 months SLIT 250,000U RAST
Outcomes	Diary scores Nasal provocation
Notes	Jadad scale 3/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Patients were randomised but how this was done was not stated
Allocation concealment?	Unclear risk	This was not stated
Blinding? All outcomes	Low risk	Investigators and participants were blinded to treatment assignment for the duration of the study
Incomplete outcome data addressed? All outcomes	Low risk	All patients completed the study
Free of selective reporting?	Low risk	The specified outcomes in the methodology were reported in the results section
Free of other bias?	Unclear risk	Insufficient information to assess whether an important risk of bias exists