Hirsch 1997.

Methods	Randomised DBPC trial
Participants	Children 15 active (10 m) 15 placebo (10 m)
Interventions	12 months SLIT cumulative dose 570 mcg Derp 1
Outcomes	Diary scores SPT
Notes	Jadad scale 5/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk	Subjects were randomised according to a code provided by the manufacturer
Allocation concealment?	Low risk	Central allocation
Blinding? All outcomes	Low risk	Investigators and participants were blinded to treatment assignment for the duration of the study
Incomplete outcome data addressed? All outcomes	Low risk	Participants lost to follow‐up or excluded were accounted for along with patients followed to designated follow‐up periods
Free of selective reporting?	Low risk	The specified outcomes in the methodology were reported in the results section
Free of other bias?	Unclear risk	Insufficient information to assess whether an important risk of bias exists