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. 2019 Dec 14;28(2):561–571. doi: 10.1016/j.ymthe.2019.11.030

Figure 4.

Figure 4

Heterogeneic Integration Pattern of TEG001 Insert in TEG001 Drug Product

(A) TLA sequence coverage across the human genome using the TEG001 specific primer set 1. No coverage peaks are visible. The different chromosomes are indicated on the y axis, and the chromosomal position on the x axis. One representative sample out of four is shown (TEG001-28). (B) Many integration sites are found in TEG001 drug product samples as an indication of a heterogeneic integration pattern. Coverage and number of different genome fusion sites are indicated per sample for the two positions in the LTR sequence that are fused to the human host genome. The data from primer sets 1 and 2 are combined.