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. 2019 Dec 6;28(2):548–560. doi: 10.1016/j.ymthe.2019.11.028

Figure 7.

Figure 7

GM7 CAR T Cells Do Not Mediate Detectable On-target Off-tumor Toxicity

GM7-27Z and CD19 CAR T cells were tested in 16-h chromium-release lysis assays at E:T ratios of 1:1 to 10:1. MC813-70 CAR T cells, known to exhibit normal tissue toxicity, were used as a positive control. In addition, the various CAR T cells were tested on C30 or C30.MISIIR tumor cell lines. Data are represented as mean ± SD. Statistical comparisons were determined by two-way ANOVA and Dunnett’s multiple comparison test as compared to CD19 CAR. **p < 0.01, ***p < 0.001, ****p < 0.0001.