Figure 6.

Patient time courses. Summary of the clinical course and blood biomarker readouts of six patients with SCLC: L18 (A), L19 (B), L21 (C), E20 (D), E30 (E), and E29 (F). In each plot, the x axis indicates the days of follow-up with the time point corresponding to day 0 as diagnosis. The clinical events are indicated in blue along the top of each plot, the circulating free DNA (cfDNA) samples are indicated along the x axis as baseline (BL), end of treatment (eTx), follow-up 1 (prerelapse clinic appointment [FU1 or FU]), follow-up 2 (prerelapse clinic appointment [FU2]), and relapse (R). The treatment received and the duration of treatment by the patient are indicated by the colored boxes on each plot, with yellow representing first-line carboplatin/etoposide, blue for second-line carboplatin/etoposide, light green for prophylactic cranial irradiation (PCI), and dark green for radiotherapy. Abbreviations: PGA, percent genome amplified; TP53, tumor protein p53 gene; VAF, variant allele fraction.