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. 2019 Nov 13;4(6):e000572. doi: 10.1136/esmoopen-2019-000572

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© Author (s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Concordance analysis of matched plasma/urine samples in CRC patients. Mutations found in the tumour tissue and in both matched plasma and urine ctDNA are shown. ‘Concordance’ indicates the number of somatic mutations shared between plasma and urine samples. For cases CRC-UD21 and CRC-UD24, the average frequency of each mutation identified in two urine samples is reported. Coloured-scale is used to show fractional abundance for each mutation. (A) Cancer patients with low tumour content identified in urine ctDNA. (B) Cancer patients with high tumour content identified in urine ctDNA. CRC, colorectal cancer; ctDNA, circulating free tumour DNA; trtDNA, trans-renal tumour DNA.