Table 2.
Hazard of Incident Seizure, Among Those Without a Baseline Seizure
| Baseline Characteristica | HR (95% CI) | P Value |
|---|---|---|
| Cohort | ||
| 2010–2012 (COAT Trial) | Reference | |
| 2013–2017 (ASTRO Trials) | 2.28 (1.23–4.23) | <.01 |
| Age, years | 1.00 (0.98–1.03) | .45 |
| Women | 1.62 (1.05–2.49) | .03 |
| Glasgow Coma Score <15 | 1.05 (0.65–1.67) | .84 |
| CSF opening pressure, cm H20 | 1.00 (0.99–1.02) | .27 |
| Quantitative culture, log10 CFU/mL CSF | 1.20 (1.03–1.40) | .01 |
| CD4 <100 cells/μL | 1.02 (0.43–2.38) | .96 |
Abbreviations: CFU, colony-forming units; COAT, Cryptococcal Optimal ART Timing; CSF, cerebrospinal fluid; HR, hazard ratio.
aFull model adjusted for study cohort, age, sex, baseline Glasgow Coma Score <15, CSF opening pressure, CSF fungal burden, and CD4 <100 cells/μL.