Fig. 2.

RSPO2 deficiency promotes neutrophil accumulation. a, b Quantification of ICC of MPO + cells in the BALF of RSPO2^+/+ mice and RSPO2^−/− mice 48 h after TM administration. An arrow indicates examples of DAPI/MPO-double stained cells. c qPCR analysis demonstrating a similar increase in MPO transcript in cells present in BALF of RSPO2^−/− mice. Representative images are shown from RSPO2^+/+ mice (n = 3) and RSPO2^−/− mice (n = 3) samples. * = A P value of less than 0.05 was considered significant