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. 2020 Feb 5;18:56. doi: 10.1186/s12967-020-02235-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Differentially expressed miRNA/mRNA (MTG) pairs impact the overall survival of melanoma patients. a Pearson correlation matrix between immune cell types and differentially expressed miRNAs (DEM). Only correlation with abs(r) ≥ 0.4 and p-value ≤ 0.05 are shown. The immune cell types enriched in G2 and the miRNAs upregulated in G2 are highlighted in green and those in G3 in orange. b Heat map showing the expression pattern of miRNAs and target genes among samples, which were hierarchical clustered using distance as 1 − Pearson correlation coefficient. Data represent RNA-seq normalized pseudocounts in log2 scale, z-score transformed by rows. c Network highlighting the interactions between MTG pairs. The putative circulating miRNAs reported by miRandola are identified as triangles and their targets as stars. Gene expression in melanoma cells was accessed in the CCLE database. Node colors represent the gene expression levels in G3 related to G2. All genes in the network labeled in italic have an impact on patients’ survival