Table 5.

A selected list of GPI-anchored genes that when mutated give rise to overlapping phenotypes with CDG patients

HPO Term	GPI-anchored genes
	APLI	ALPL	ALPP	ALPPL2	CNTN1	FOLR1	GPC6	GPC3	CD59	CNTN2	GPIHBP1	CD55
Hyperphosphatasia	x	x	x	x
High palate					x
Hypertelorism					x			x
Muscular hypotonia					x			x	x
Generalized hypotonia								x	x
Polyhydramnios					x
Feeding difficulties					x
Camptodactyly					x
Intellectual disability						x
Seizures						x				x
Malar flattening							x
Epicanthus							x	x
Micrognathia							x
Depressed nasal bridge							x	x
Wide nasal bridge							x	x
Short neck							x
Atrial septal defect							x
Frontal bossing							x
Short nose							x	x
Tremor										x
Cleft palate								x
Coarse facial features								x
Hepatomegaly								x			x	x
Macrocephaly								x
Patent ductus arteriosus								x
Short distal phalanx of finger								x
Small nail								x
Splenomegaly								x			x
Anteverted nares								x
Wide mouth								x
Splenomegaly								x
Failure to thrive											x
Growth delay												x