Table 2.
Status of different Smac mimetics
| Name | ClinicalTrials.gov Identifier | Phase | Condition or disease (in patients) |
|---|---|---|---|
| AZD5582 | – | Pre-clinical | – |
|
APG-1387 (SM-1387) |
NCT03386526 | Phase I | Advanced Solid Tumors or Hematologic Malignancies |
| NCT03585322 | Phase I | Chronic Hepatitis B | |
| ASTX660 | NCT04155580 | Phase I | Relapsed/Refractory Acute Myeloid Leukemia |
| NCT02503423 | Phase I/II | Advanced Solid Tumors and Lymphomas | |
|
Birinapant (TL32711) |
NCT02587962 | Phase I/II | Solid Tumors |
| NCT00993239 |
Phase I (Completed) |
Refractory Solid Tumors or Lymphoma | |
| NCT01188499 |
Phase I (Completed) |
Advanced or Metastatic Solid Tumors | |
| NCT01940172 |
Phase I (Completed) |
Relapsed Ovarian Cancer | |
| NCT01573780 |
Phase I (Terminated – safety unrelated issue) |
Advanced Solid Tumors | |
| NCT01681368 |
Phase II (Terminated – lack of a clinical benefit) |
Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer | |
|
Debio 1143 (AT-406, SM-406) |
NCT04122625 | Phase I | Solid Tumor |
| NCT03270176 | Phase I | Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy | |
| NCT03871959 | Phase I | Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma | |
| NCT02022098 | Phase I/II | Squamous Cell Carcinoma of the Head and Neck | |
| NCT01078649 |
Phase I (Completed) |
Advanced Solid Tumors and Lymphomas | |
| GDC-0152 | NCT00977067 |
Phase I (Terminated – safety unrelated issue) |
Locally Advanced or Metastatic Malignancies |
| LCL161 | NCT02649673 | Phase I | Relapsed/Refractory Small Cell Lung Cancer (SCLC) and Select Gynecologic Malignancies |
| NCT03111992 | Phase I | Multiple Myeloma | |
| NCT01968915 |
Phase I (Completed) |
Advanced Solid Tumors | |
| NCT02098161 | Phase II | Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis | |
| NCT01955434 |
Phase II (Completed) |
Relapsed or Refractory Multiple Myeloma | |
| WX20120108 | – | Pre-clinical | – |