Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 4;8:12. doi: 10.1186/s40478-020-0890-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — Localization of TTBK1 and pCRMP2 in the pyramidal neurons of the EC and CA1–3 hippocampal regions in early AD brains. The human brain specimens are listed in Table 1. a Deparaffinized human brain sections (8 μm in thickness) containing the EC layer II and CA1 hippocampal regions from patients in Braak I-IV were DAB immunostained for TTBK1 and counterstained with hematoxylin. Top panel: EC regions, bottom panel: CA1 region. Scale bar = 20 μm. b Immunofluorescence of Braak II EC brain sections with AT8 (pSer202/205 tau, green), TTBK1 (red) and Dapi (blue). Scale bar = 10 μm. c DAB immunostaining with 3F4 (pCRMP2) in the EC layer II and CA1 hippocampal regions from patients in Braak I-IV. Scale bar = 20 μm. d Co-localization of 3F4 (pCRMP2) and pSer422 Tau in the CA1 region of Braak I brain sections (indicated by *). Scale bar = 40 μm