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. 2020 Feb 4;8:12. doi: 10.1186/s40478-020-0890-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Transgenic expression of APP and TTBK1 induces axonal degeneration of EC neurons. a Stereotaxic DiI injection into stratum moleculare of dentate gyrus (DG) of a fixed and vibratome sectioned mouse brain. Transgenic littermates were sacrificed at 10 months of age and fixed brain tissues were injected with 0.5 μL of DiI. DG (a), PP (b) and MEC (c) regions were illustrated from the sections proximal to ML + 2.4 (a), + 2.7 (b) and + 2.9 (c). b DiI-labeled axon tracts (red) counterstained with Dapi (blue) in the DG, PP, and MEC in Non-Tg, APP, TTBK1, and APP/TTBK1 mice. c Retrograde tracing of DiI in the layer II/III region of EC of transgenic littermates. d DiI intensity measurements in the region of interest (ROI) of the layer II/III region of MEC. The error bars indicate SEM. * denotes p < 0.05 as determined by one-way ANOVA and Tukey post hoc (N = 6 per group). ANOVA F (3,20) = 82.48 (p < 0.0001)