Fig. 10.

Exosomal miR-216a-5p regulates microglial M1/M2 polarization through TLR4/NF-κB/PI3K/AKT signaling cascades. a Representative images and quantification of western blots for TLR4 and downstream MyD88/NF-κB and PI3K/AKT signaling cascades in LPS-stimulated BV2 microglia when administrating PBS, HExos, miR-NC^OE-HExos and miR^OE-HExos. b Representative images and quantification of western blots for TLR4 and downstream MyD88/NF-κB and PI3K/AKT signaling cascades in LPS-stimulated primary microglia when administrating PBS, HExos, miR-NC^KD-HExos and miR^KD-HExos