Table 2.
Demographic and cognitive characteristics of the PSP patients and healthy controls from the “PiPPIN” regional epidemiological study
| PSP patients (n = 31) | PSP-RS (n = 22) | Variant PSP (n = 9) | Controls (PiPPIN) (n = 60) | p-value Control – PSP | |
|---|---|---|---|---|---|
| Age at testing | |||||
| Mean ± SD | 73.3 ± 7.7 | 71.02 ± 7.3 | 79.9 ± 5.6 | 71.4 ± 6.0 | n.s.a |
| Number (%) of males | 19 (61%) | 14 (63%) | 5 (56%) | 30 (50%) | n.s.b |
| Interval to death (year) | |||||
| Mean ± SD | 1.8 ± 0.9 | 2.2 ± 0.8 | 1.8 ± 0.8 | – | – |
| PSPRS | n = 23 | n = 19 | n = 3 | ||
| Mean ± SD | 48.9 ± 14.1 | 47.9 ± 14.1 | 55 ± 15.1 | 0.32 ± 0.99 | t45 = 17.2, p = 2.2e− 21 |
| ACER | |||||
| Mean ± SD | 64.2 ± 16.0 | 65.0 ± 15.0 | 62.4 ± 19.2 | 95.7 ± 4.4 | t89 = 14.3, p = 9.5e− 25 |
| CBI-R | n = 24 | n = 17 | n = 7 | ||
| Mean ± SD | 84.5 ± 52.7 | 83.6 ± 52.1 | 86.4 ± 52.7 | 6.8 ± 7.3 | t82 = 11.3, p = 2.6e− 18 |
| MMSE | |||||
| Mean ± SD | 21.9 ± 4.8 | 22.3 ± 4.4 | 21 ± 5.8 | 29.4 ± 0.9 | t89 = − 11.6, p = 1.4e− 19 |
For PSPRS and CBI-R the n above the mean indicates the number of patients from which data was available. The controls were healthy, age and sex-matched controls from a regional population cohort, PiPPIN [17]. PSP progressive supranuclear palsy, PSP-RS PSP Richardson’s syndrome, PiPPIN “Pick’s disease and progressive supranuclear palsy prevalence and incidence study” [17], PSPRS PSP rating scale, ACER revised Addenbrooke’s cognitive examination, CBI-R revised Cambridge Behavioural Inventory, MMSE Mini Mental State Examination, SD standard deviation, n.s. not significant, p > 0.05, by a Student’s t-test or b Fischer’s exact test. Subscript to t is degrees of freedom. Uncorrected p-values