Table 2.

Drug-induced melanonychia

Drugs	Features
Chemotherapeutic agents-Cyclophosphamide, doxorubicin, hydroxyurea, busulfan, taxanes, capecitabine, cisplatin, bleomycin, daunorubicin, dacarbazine, 5-FU, methotrexate	Seen 1-2 months after initiation
	One or more transverse or longitudinal bands
	Cyclophosphamide-Diffuse black, longitudinal, or dark gray pigmentation of proximal nail plate[14]
	Doxorubicin: Alternating bands of dark brown and white lines, and transverse bands[14] Hydroxycarbamide: Distal or diffuse, dark brown[14]
ART-Zidovudine, Lamivudine	Diffuse blue-brown, transverse or longitudinal bands
	Fingernails > toenails.
	Appears after 3-8 weeks
	Reversible within 6-8 weeks, may persist for months
Antimalarials-Amodiaquine, chloroquine, mepacrine, quinacrine	Melanonychia due to melanin and ferric dyschromia[3]
Others-Biologicals, clofazimine, infliximab, psoralens, phenytoin, fluconazole, cyclins, ketoconazole, phenothiazines, sulphonamides Metals-Arsenic, Thallium, Mercury	Diffuse pigmentation, multiple nails