Appendix 1.
Item pool and global quality of life
| n | Item | Fate of item# | Frequency | Mean response | Impact |
|---|---|---|---|---|---|
| q1 | Do you take more time in daily routine activities (such as bathing, dressing, and taking food.) compared to predisease state? | ADL | 0.89 | 1.74 | 1.55 |
| q2 | To what extent your tremors disturb you? | ADL | 0.89 | 2.15 | 1.91 |
| q3 | Is there any change in your voice? | ADL | 0.84 | 1.45 | 1.21 |
| q4 | Do you have difficulty in turning in bed or taking blankets? | ADL | 0.75 | 1.45 | 1.08 |
| q5 | Do you have difficulty in daily routine activities such as toileting, brushing teeth, bathing, dressing, and eating? | ADL | 0.82 | 1.43 | 1.17 |
| q6 | Do you feel difficult in getting up from chair? | ADL | 0.70 | 1.23 | 0.86 |
| q7 | Do you feel difficulty in walking? | Mobility | 0.91 | 1.64 | 1.48 |
| q9 | Do you feel difficulty in turning while walking? | Mobility | 0.71 | 1.29 | 0.92 |
| q10 | Do you feel that your feet get glued (freeze) to the floor while walking, making a turn or initiate walking? | Mobility | 0.63 | 1.42 | 0.90 |
| q11 | Do you fall while walking? | Mobility | 0.37 | 0.63 | 0.24 |
| q12 | Do you get angry? | Deleted | 0.83 | 1.63 | 1.36 |
| q13 | Do you feel weepy? | Psychological | 0.53 | 0.93 | 0.49 |
| q14 | Do you feel like living alone? | Deleted | 0.37 | 0.66 | 0.25 |
| q15 | Do you feel excited to start any new task? | Deleted | 0.72 | 2.06 | 1.48 |
| q16 | Do you feel ignored (people neglect you)? | Deleted | 0.49 | 0.90 | 0.44 |
| q17 | Do you feel anxious/tensed? | Psychological | 0.74 | 1.60 | 1.18 |
| q18 | Do you feel that it’s better to die than this sort of life? | Psychological | 0.41 | 0.89 | 0.37 |
| q19 | Do you feel you are sad? | Psychological | 0.72 | 1.43 | 1.02 |
| q20 | Do you have difficulty in concentration? | Deleted | 0.66 | 1.35 | 0.89 |
| q21 | Do you worry for progression of the disease? | Fear | 0.86 | 2.05 | 1.76 |
| q22 | Does the changed attitude of others due to the disease, disturb you? | Fear | 0.58 | 1.21 | 0.70 |
| q23 | Is it difficult for you to accept the disease? | Fear | 0.66 | 1.47 | 0.98 |
| q24 | Are you afraid of what’s there in your destiny? | Fear | 0.64 | 1.56 | 0.99 |
| q25 | Do your unusual behavior like suspecting others without any reason, disturb you? | Deleted | 0.39 | 0.80 | 0.31 |
| q26 | Have you ever tried to commit suicide? | Deleted | 0.05 | 0.18 | 0.01 |
| q27 | Is there any change in your self-confidence? | Deleted | 0.73 | 1.24 | 0.90 |
| q28 | Is there any change in religious faith due to disease? | Deleted | 0.44 | 0.82 | 0.36 |
| q29 | Do you feel embarrassed/ashamed while eating/drinking in front of strangers? | Deleted | 0.56 | 1.17 | 0.65 |
| q30 | Due to disease, do you feel embarrassed/ashamed in the society? | Social | 0.58 | 1.24 | 0.72 |
| q31 | Is it difficult for you to ask help from others? | Social | 0.60 | 1.29 | 0.78 |
| q32 | Do you feel difficulty in talking to strangers? | Social | 0.51 | 1.10 | 0.56 |
| q33 | Is your family disturbed because of you? | Family | 0.50 | 1.21 | 0.61 |
| q34 | Do you have become dependent on others due to disease? | Family | 0.63 | 1.46 | 0.92 |
| q35 | Can you fulfill your family responsibilities? | Family | 0.68 | 1.73 | 1.18 |
| q36 | Do you get support (as expected by you) from your family? | Deleted | 0.38 | 0.78 | 0.29 |
| q37 | Can you do your business or job-related work? | Deleted | 0.75 | 2.22 | 1.65 |
| q38 | Can you do your household chores (such as cooking, washing clothes, and dusting)? | Deleted | 0.75 | 2.22 | 1.67 |
| q39 | Do you have spat/brawl in family due to disease? | Deleted | 0.40 | 0.68 | 0.27 |
| q40 | Is there any change in your social outings/meetings? | Social | 0.68 | 1.23 | 0.83 |
| q41 | What is the change in your life with Parkinson’s disease medication? | Treatment | 0.89 | 2.15 | 1.91 |
| q42 | Does dependency on medication disturb you? | Deleted | 0.73 | 1.74 | 1.27 |
| q43 | Shortly after taking the medicine, is the medicine less effective or ineffective? | Treatment | 0.73 | 2.88 | 2.11 |
| q44 | Do side effects of the drugs are a problem for you? | Deleted | 0.58 | 1.32 | 0.76 |
| q45 | Dyskinesia (movement of your body against your desire) is a problem for you? | Deleted | 0.67 | 1.68 | 1.13 |
| q46 | The loss of appetite or weight loss is a problem for you? | Deleted | 0.42 | 0.91 | 0.38 |
| q47 | Do you see something (such as someone is sitting in the room), which does not really exist? | NMS | 0.28 | 0.61 | 0.17 |
| q48 | Do visit to hospital, meeting doctors, and treatment-related work is a problem for you? | Deleted | 0.53 | 1.21 | 0.65 |
| q49 | Are you satisfied with your treatment? | Treatment | 0.69 | 1.53 | 1.06 |
| q50 | Due to disease, is there any effect on yours or your family’s income? | Financial | 0.57 | 1.10 | 0.62 |
| q51 | Due to disease, have you or your spouse declined anything related to financial benefit such as promotion and project? | Deleted | 0.23 | 0.88 | 0.20 |
| q52 | Due to disease, have you or your spouse left his/her business or job? | Deleted | 0.22 | 0.84 | 0.18 |
| q53 | To what extent expenditure on treatment bothers you? | Financial | 0.66 | 1.58 | 1.05 |
| q54 | Is there any effect on important works of family (such as education of children, marriage, and construction of house) due to increase in expenditure on treatment? | Financial | 0.54 | 1.28 | 0.70 |
| q55 | Is there any change in your memory? | NMS | 0.68 | 0.95 | 0.64 |
| q56 | In the last 4 weeks, how much you were bothered due to constipation (No bowel movement for 3 days)? | NMS | 0.57 | 1.38 | 0.78 |
| q57 | Do you feel helpless due to fatigue? | NMS | 0.83 | 1.87 | 1.56 |
| q58 | Are you bothered due to drooling of saliva? | NMS | 0.48 | 0.95 | 0.46 |
| q59 | Are you disturbed due to sleep? | NMS | 0.55 | 1.23 | 0.68 |
| q60 | Are you disturbed with body aches due to disease? | NMS | 0.72 | 1.66 | 1.20 |
| q61 | Are you disturbed due to coldness, burning or numbness of hands and feet? | NMS | 0.63 | 1.38 | 0.87 |
| q62 | Are you bothered due to urinary problem (going frequently or soiling of clothes)? | NMS | 0.63 | 1.36 | 0.85 |
| q63 | Do you feel difficulty in swallowing food? | NMS | 0.33 | 0.59 | 0.19 |
| q64 | Are you bothered due to vision-related problems (double vision, appearance of lights or flashes)? | Deleted | 0.41 | 0.77 | 0.31 |
| q65 | While sleeping, do you grumble or move your hands and legs, like you are acting a dream? | NMS | 0.53 | 1.13 | 0.60 |
| q66 | Do you feel restlessness or fidgety in legs while sitting idle or lying which gets relieved with leg mobility? | NMS | 0.56 | 1.14 | 0.64 |
| q67 | Do you get hold of weird dreams? | Deleted | 0.49 | 0.97 | 0.47 |
| q68 | Are you satisfied with your sexual life? | NMS | 0.60 | 1.56 | 0.93 |
| q69 | Are you satisfied with your health? | NMS | 0.84 | 2.38 | 2.00 |