Skip to main content
. 2020 Jan 9;21(2):e48781. doi: 10.15252/embr.201948781

Figure EV1. Characteristics of a mouse model of type 2 diabetic nephropathy.

Figure EV1

  • A
    Schema illustrating mouse model of type 2 diabetic nephropathy (DN) using high fat diet (HFD) and a single‐dose streptozotocin (50 mg/kg) intraperitoneal injection.
  • B
    Increment change of body weight in eNOS+/+ ND, eNOS+/+ HFD+STZ, eNOS−/− ND and eNOS−/− HFD+STZ.
  • C, D
    HbA1c% (C) and plasma insulin level (D) change in eNOS+/+ ND, eNOS+/+ HFD+STZ, eNOS−/− ND and eNOS−/− HFD+STZ after 24 weeks of treatment.
  • E
    Periodic acid–Schiff (PAS) staining of sections from eNOS+/+ ND, eNOS+/+ HFD+STZ, eNOS−/− ND and eNOS−/− HFD+STZ mouse kidneys. Scale bars: 50 µm.
  • F
    Urinary albumin/creatinine ratio changes from eNOS+/+ ND, eNOS+/+ HFD+STZ, eNOS−/−ND and eNOS−/− HFD+STZ mouse.
  • G
    Serum cystatin C changes from eNOS+/+ ND, eNOS+/+ HFD+STZ, eNOS−/− ND and eNOS−/− HFD+STZ mouse.
Data information: One‐way ANOVA was performed. Data are shown as mean ± SD from groups of eight mice. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, N.S, P > 0.05.