Figure EV4. Smad4 deficiency in podocytes protects mice from type 2 diabetic nephropathy.

• A–D
  Changes in body weight, fasting blood glucose levels, HbA1c and plasma insulin in ND‐treated or HFD+STZ‐treated eNOS^−/− PodCre mice or eNOS^−/− PodCre‐Smad4^−/− mice.
• E, F
  Glucose tolerance test (E) and quantification of glucose tolerance test (F) in ND‐treated or HFD+STZ‐treated eNOS^−/− PodCre mice or eNOS^−/− PodCre‐Smad4^−/− mice.

Data information: One‐way ANOVA was performed. Data are shown as mean ± SD from groups of eight mice. N.S, P > 0.05; ***P < 0.001; ****P < 0.0001.