Figure 1. Changes in body weight and energy expenditure in 5‐month‐old mice.

Eight‐week‐old male WT and DOCK5^−/− mice were fed a standard diet (SD) or high‐fat diet (HFD) for 3 months.

1. Body weight curve.
2. Cumulative body weight.
3. Average daily food intake.
4. Fasting and fed blood glucose.
5. Rectal temperature.
6. Locomotor tolerance.
7. 24‐h oxygen consumption.
8. Respiratory exchange ratio (RER: V_CO2/V_O2).
9. Energy expenditure.

Data information: Data are expressed as the mean ± SEM (n = 6 mice for each group). SD, standard chow diet; HFD, high‐fat diet. P‐values were determined with two‐way ANOVA, ^# P < 0.05, ^## P < 0.01 versus SD‐WT; *P < 0.05, **P < 0.01 versus HFD‐WT.