Figure EV5. Changes in body weight and energy expenditure in 18‐month‐old mice.

Eight‐week‐old male WT and DOCK5^−/− mice were fed a SD or a HFD for 16 months.

1. Body weight curve.
2. Cumulative body weight.
3. Average daily food intake.
4. Fasting and fed blood glucose.
5. Rectal temperature.
6. Locomotor tolerance.
7. V_O2.
8. RER.
9. Energy expenditure.
10. GTTs.
11. ITTs.

Data information: SD, standard chow diet; HFD, high‐fat diet. Data are expressed as the mean ± SEM (n = 5–6 for each group). ^# P < 0.05, ^## P < 0.01 versus SD‐WT; P‐values were determined with two‐way ANOVA. *P < 0.05, **P < 0.01 versus HFD‐WT.