Figure 2. HO‐1 deficiency affects expression of hematopoietic factors in ECs and CARs.

• A
  RNA‐seq revealed 111 DEGs in HO‐1^−/− ECs.
• B, C
  The identified DEGs separated HO‐1^−/− and HO‐1^+/+ ECs by (B) hierarchical clustering and (C) PCA.
• D
  Selected GOBP terms enriched in GSEA in HO‐1^−/− ECs.
• E, F
  Heatmap of selected (E) hematopoietic factors and (F) adhesion molecules expression in HO‐1^−/− and HO‐1^+/+ ECs.
• G
  RNA‐seq revealed 100 DEGs in HO‐1^−/− CARs.
• H, I
  The identified DEGs separated HO‐1^−/− and HO‐1^+/+ CARs by (H) hierarchical clustering and (I) PCA.
• J
  Selected GOBP terms enriched in GSEA in HO‐1^−/− CARs.
• K, L
  Heatmap of selected (K) skeletal biology and (L) hematopoietic factors expression in HO‐1^−/− and HO‐1^+/+ CARs. Correlation similarity metric and average linkage clustering were used in the presented heatmaps.

Data information: Color key on the heatmaps represents gene expression (as z‐score among row) red—high expression, blue—low expression.