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Conjugated plasma bile acid levels increase upon Myrcludex B treatment in mice. (A-B) Total plasma bile acid levels (A) and the distribution in conjugated and unconjugated bile acid species (B) of Oatp1a/1b KO mice treated with Myrcludex B (2.5 mg/kg, subcutaneous injection). Blood was drawn at indicated time-points (n = 3–8), circle size represents the total amount of bile acids. Data is represented as mean ± SEM. KO, knockout.
