Table 3.

Multivariable CRR according to the Fine and Gray method with backward selection of factors associated to the development of ACLF during hospitalization.

Parameter	sHR (95% CI)	p value
MELD score (1-point increase)	1.15 (1.10–1.21)	≪0.001
Hemoglobin (1 g/dl increase)	0.81 (0.68–0.96)	0.018
Leukocyte (109/L increase)	1.11 (1.06–1.16)	≪0.001

In-hospital mortality, liver transplantation and hospital discharge were considered as competing events. Data are presented as sub-distribution hazard ratio and 95% CI. Variable entered in the first step included also ascites, serum albumin, C-reactive protein and heart rate at hospital admission. The disease severity score to be included in the analysis was selected by the receiver-operating characteristic analysis.

ACLF, acute-on-chronic liver failure; CRR, competing risk regression; MELD, model for end-stage liver disease.