Table 4.

Multivariable CRR according to the Fine and Gray method with backward selection of factors associated with the development of ACLF during hospitalization.

Parameter	sHR (95% CI)	p value
Nosocomial infection (yes vs no)	6.80 (3.06–15.13)	≪0.001
MELD score (1-point increase)	1.13 (1.08–1.18)	≪0.001
Hemoglobin (1 g/dl increase)	0.82 (0.69–0.99)	0.040
Leukocyte (109/L increase)	1.12 (1.07–1.17)	≪0.001

In-hospital mortality, liver transplantation and hospital discharge were considered as competing events. Data are presented as sub-distribution hazard ratio and 95% confidence interval. Variable entered in the first step included also ascites, serum albumin, C-reactive protein and heart rate at hospital admission. The disease severity score to be included in the analysis was selected by the receiver-operating characteristic analysis.

ACLF, acute-on-chronic liver failure; CRR, competing risk regression; MELD, model for end-stage liver disease.