Table 1.

Association of new loci with risk of DLBCL

SNP	Nearest gene	Position	Stage	Study	i/g	Information content	Controls (N)	Cases (N)	Effect allele	ref allele	Effect allele MAF, controls	Effect allele MAF, cases	OR	P	Phet	I2
rs9831894	CD86	121 800 487	Discovery	NCI	i	0.99	6221	2660	C	A	0.40	0.35	0.81	3.08 × 10−9
				GELA	g	1	525	549	C	A	0.39	0.37	0.94	0.473
				MAYO	g	1	172	393	C	A	0.39	0.35	0.82	0.151
				UCSF2	g	1	748	254	C	A	0.38	0.37	0.94	0.593
				META (6)			7666	3856					0.84	4.52 × 10 –9	0.30	18.3
			Replication	MAYO	g	1	1053	782	C	A	0.40	0.34	0.79	4.57 × 10−4
				MDA	g	1	370	371	C	A	0.39	0.33	0.78	0.022
				MSKCC	g	1	148	653	C	A	0.33	0.32	0.93	0.617
				META			1571	1806					0.80	4.17 × 10 –5	0.54	0
				Combined discovery and replication			9237	5662					0.83	3.62 × 10 –13	0.51	0
rs6773363	EOMES	27 793 632	Discovery	NCI	i	0.98	6220	2660	C	T	0.45	0.49	1.16	2.34 × 10−5
				GELA	i	0.98	525	548	C	T	0.45	0.45	0.99	0.917
				MAYO	i	0.98	171	393	C	T	0.47	0.51	1.22	0.129
				UCSF2	i	0.94	747	253	C	T	0.42	0.52	1.48	1.57 × 10−4
				META (6)			7663	3854					1.17	3.68 × 10 –7	0.03	65.24
			Replication	NCI	g	1	3349	196	C	T	0.47	0.48	1.05	0.67
				MSKCC	g	1	372	428	C	T	0.45	0.54	1.41	2.01 × 10−3
				MDA	g	1	374	373	C	T	0.45	0.51	1.30	0.01
				MAYO	g	1	1059	659	C	T	0.47	0.53	1.31	1.59 × 10–4
				META			5154	1656					1.27	3.78 × 10 −7	0.22	32.05
				Combined discovery and replication			12 817	5510					1.20	2.31 × 10 −12	0.03	53.76

MAF, minor allele frequency; i/g, imputed/genotyped; and P_het, P-value for heterogeneity