Table 3.
Test substances | Dose (mg/kg/day) | Pretreatment rectal temperature | Posttreatment rectal temperature | Percentage change % |
---|---|---|---|---|
Distilled water | 0.2 ml | 35.9 ± 0.34 | 33.3 ± 0.31 | −0.4 |
| ||||
Methanol extract | 100 mg | 35.8 ± 0.28 | 35.8 ± 0.22 | +0.1a∗c∗∗d∗ |
200 mg | 36.5 ± 0.26 | 36.5 ± 0.23 | +0.3a∗c∗∗d∗ | |
400 mg | 37.0 ± 0.21 | 37.5 ± 0.32 | +0.5a∗c∗∗d∗ | |
| ||||
Aqueous extract | 100 mg | 36.4 ± 0.24 | 33.3 ± 0.25 | −0.5 |
200 mg | 36.9 ± 0.20 | 34.3 ± 0.19 | −0.3 | |
400 mg | 35.9 ± 0.17 | 33.4 ± 0.18 | −0.4 | |
| ||||
Chloroquine | 25 mg | 36.2 ± 0.15 | 36.7 ± 0.12 | +0.7a∗b∗c∗ |
Values are presented as M ± SEM; n = 5. ∗∗(p < 0.01); ∗(p < 0.001); a = compared to negative control; b = compared to 80% methanol extract; c = compared to aqueous extract; d = compared to chloroquine.