Table 3.

Multivariate Cox proportional hazard analysis of overall survival in the UK LRF CLL4 patients (cases, n = 297; events, n = 231)

Variable	Hazard ratio	95% Confidence interval	P-value
EGR2 mutation status	1.95	1.02–3.73	0.043
Age	1.72	1.32–2.24	<0.001
Gender	1.44	1.04–1.99	0.029
Binet stage	1.21	0.86–1.71	0.271
IGHV mutation status	2.22	1.64–2.99	<0.001
del(11q)(q22)	1.46	1.07–1.99	0.018
TP53abn	4.85	2.90–8.11	<0.001

Abbreviation: TP53abn, TP53 aberrations (that is, mutations and/or deletions).