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. 2019 Dec 3;4:193. [Version 1] doi: 10.12688/wellcomeopenres.15590.1

Figure 2. Sequence diversity of var1CSA genes from clinical isolates.

Figure 2.

var1CSA genes were split into two major types corresponding to P. falciparum 3D7 (top) and P. falciparum IT (bottom) var1CSA reference genes, based on a phylogenetic analysis (Addition File 2: Figure S1). Using BWA-MEM and SAMtools Pileup, sequence identity and polymorphism were detected and then plotted across each reference. The regions of each gene encoding specific protein domains are indicated. Genes of the 3D7 type have high sequence identity across their entire length but those of the IT type show greater polymorphism, particularly in their 3’ half.