Table 3:

Risk of vascular events during follow-up time (10.4 ± 3.1 year, range 0.5–14.8) by covert infarct subtype

	Covert infarcts at the time of MRI Hazard ratios, 95% Confidence Interval
	Any N=236	Distal cryptogenic N=144	Distal cardioembolic N=29	Intracranial large artery stenosis N=23	Isolated penetrating artery N=37
Any death (N=398)	1.42, 1.12–1.80	1.43, 1.08–1.90	1.40, 0.81–2.44	2.24, 1.29–3.88	1.53, 0.88–2.65
Vascular death (N=−162)	1.48, 1.18–1.87	1.43, 1.08–1.90	1.41, 0.81–2.45	2.24, 1.29–3.88	1.53, 0.88–2.65
Myocardial Infarction (N=60)	1.48, 1.18–1.84	1.40, 1.07–1.85	1.65, 0.97–2.81	2.34, 1.41–3.92	1.37, 0.81–2.33
Any stroke (N=117)	1.50, 1.21–1.86	1.44, 1.11–1.89	1.51, 0.92–2.47	2.16, 1.27–3.67	1.61, 0.98–2.65
Any vascular events (N=288)	1.47, 1.18–1.80	1.37, 1.05–1.78	1.78, 1.10–2.89	2.22, 1.35–3.66	1.39, 0.84–2.27
Ischemic stroke (N=99)	1.49, 1.20–1.86	1.44, 1.10–1.89	1.48, 0.90–2.42	2.21, 1.30–3.75	1.63, 1.00–2.68
Cryptogenic stroke (N=16)	1.48, 1.18–1.87	1.45, 1.10–1.92	1.36, 0.78–2.36	2.16, 1.25–3.74	1.51, 0.87–2.61
Cardioembolic stroke (N=40)	1.49, 1.19–1.87	1.39, 1.05–1.84	1.59, 0.95–2.65	2.35, 1.38–4.01	1.52, 0.88–2.62
Intracranial [small and large] arterial disease stroke (N=34, 24 small & 12 large)	1.49, 1.19–1.86	1.45, 1.10–1.91	1.34, 0.78–2.28	2.07, 1.19–3.57	1.68, 1.03–2.80

Analytic notes:

-Models adjusted for age, sex, ethnicity, prevalent and incident hypertension, diabetes and hypercholesterolemia, average number of antihypertensives at MRI, Hypoglycemics and cholesterol-lowering medications at MRI, post MRI exposure (in years) to antihypertensives, hypoglycemics, statins, pack-per-year of smoking, antiplatelets and anticoagulation, and follow-up with primary care during follow-up.

-Three participants had carotid stenosis > 60% by Doppler and ipsilateral infarcts and were considered within the “any infarct” category but not in the infarct subcategories.