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. Author manuscript; available in PMC: 2020 Feb 5.
Published in final edited form as: Cell Rep. 2020 Jan 21;30(3):881–892.e5. doi: 10.1016/j.celrep.2019.12.077

Figure 1. Sequence-Based Phylogenetic Analysis of the Calpain Superfamily Reveals the Evolutionary Distance of CAPN5 from Classical Calpains.

Figure 1.

(A) Schematic representation of classical calpain heterodimers and CAPN5. CAPN5 lacks the PEF-hand domains and instead contains a C2 domain following the CBSW domain.

(B) Cartoon representation of calpain domain architecture of classical calpains and CAPN5.

(C) Phylogenetic analysis workflow.

(D) The approximated calpain superfamily tree. The unrooted tree is represented with clades colored according to their representative nomenclature: classical (green), non-classical (gray), and CAPN5-like (red). The positions of human CAPN5 and rat CAPN1 are denoted by black dots for reference.

(E) The unrooted CAPN5 sub-tree is represented with clades colored by related organisms. Bootstrap values are projected onto the tree topology.