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. Author manuscript; available in PMC: 2020 Feb 5.
Published in final edited form as: Cell Rep. 2020 Jan 21;30(3):881–892.e5. doi: 10.1016/j.celrep.2019.12.077

Figure 2. Crystal Structure of CAPN5-PC.

Figure 2.

(A) Ribbon tracing diagram representing domains PC1 and PC2 of CAPN5-PC. Catalytic residues and Trp286 are denoted by the cyan box. The G1 gating loop is denoted by the magenta box.

(B) Ribbon tracing diagram representing CAPN5-PC colored by the ConSurf evolutionary conservation scale. The orange dotted box denotes the active site groove.

(C) Active-site cleft of CAPN5-PC. Black dashes indicate the distance between the catalytic histidine and cysteine.

(D) Formed α7-region of CAPN5-PC.(E) Disordered α7-region of human CAPN1-PC (PDB: 2ARY).