FIG A1.
An example of a hypothetical randomized clinical trial where the survival curve for an experimental arm (red line) is always below the control arm curve (blue line) yet the late-emphasis test (G0,1) rejects the null hypothesis in favor of the experimental arm with one-sided p-value of 0.0046. The trial data were generated assuming 1000 patients per arm with instant accrual and 5 years of follow-up; in the control arm survival was assumed to follow an exponential distribution with constant hazard of 0.25, in the experimental arm survival was assumed to follow a piecewise exponential distribution with a hazard of 4 in the first 1.2 months and a hazard of 0.19 after the first 1.2 months.