Table 5.

Adjusted^a odds ratios (ORs) and 95% confidence intervals (CIs) for interaction between diabetes and other risk factors and Barrett’s esophagus, compared to population-based and endoscopy controls, respectively.

	Population-based Controls
	Non-Diabetes			Diabetes
	BE Case N	Control N	OR (95% CI)	BE Case N	Control N	OR (95% CI)	Pinteraction
Reflux Symptoms
No	622	1,844	Referent	60	215	0.91 (0.66–1.27)
Yes	703	594	Referent	98	86	0.73 (0.52–1.02)	0.3
Regurgitation b
No	201	925	Referent	27	134	1.00 (0.63–1.59)
Yes	434	342	Referent	40	31	0.98 (0.59–1.64)	1.0
Heartburn
No	708	1,962	Referent	62	227	0.85 (0.62–1.18)
Yes	617	476	Referent	96	74	0.77 (0.54–1.10)	0.9
Sex
Male	945	1,730	Referent	140	272	0.79 (0.62–1.02)
Female	380	708	Referent	18	29	1.01 (0.55–1.86)	0.5
BMI
<25 kg/m2	446	955	Referent	21	33	1.21 (0.68–2.15)
≥25 kg/m2	879	1,483	Referent	137	268	0.78 (0.61–1.00)	0.2
Smoking
Never	425	981	Referent	42	101	0.87 (0.59–1.30)
Ever	900	1,457	Referent	116	200	0.80 (0.61–1.05)	0.7
Age
<60 years	523	1,088	Referent	41	86	0.93 (0.61–1.41)
≥60 years	802	1,350	Referent	117	215	0.78 (0.60–1.02)	0.5
	Endoscopy Controls
	Non-Diabetes			Diabetes
	BE Case N	Control N	OR (95% CI)	BE Case N	Control N	OR (95% CI)	Pinteraction
Reflux Symptoms
No	149	383	Referent	35	108	1.05 (0.67–1.65)
Yes	662	802	Referent	95	160	0.87 (0.64–1.17)	0.5
Regurgitation c
No	170	264	Referent	14	14	1.14 (0.52–2.49)
Yes	429	359	Referent	39	38	0.76 (0.46–1.25)	0.9
Heartburn
No	191	429	Referent	36	111	1.01 (0.65–1.56)
Yes	603	737	Referent	93	156	0.87 (0.64–1.18)	1.0
Sex
Male	633	842	Referent	114	233	0.92 (0.70–1.21)
Female	183	353	Referent	16	35	0.98 (0.51–1.90)	0.8
BMI
<25 kg/m2	225	305	Referent	17	23	1.03 (0.52–2.06)
≥25 kg/m2	591	890	Referent	113	245	0.91 (0.69–1.19)	0.7
Smoking
Never	264	489	Referent	35	77	1.11 (0.70–1.76)
Ever	552	706	Referent	95	191	0.85 (0.64–1.15)	0.3
Age
<60 years	366	655	Referent	36	77	1.17 (0.74–1.84)
≥60 years	450	540	Referent	94	191	0.84 (0.62–1.13)	0.2

^aAdjusted for age (continuous), sex, smoking (never, ever), body mass index (continuous), and parent study.

^bAvailable for FINBAR, NDB, and SDH.

^cAvailable for FINBAR, SDH, and UNC.