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. 2020 Feb 5;15(2):e0228198. doi: 10.1371/journal.pone.0228198

Table 2. Detailed information about the classical risk factors included in the model.

Risk factor Variable name Variable type
Family history (presence or absence of disease among first degree relatives) famhist Binary
 Presence
 Absence
Age at menarche (years) menarche_dec Categorical:
 ≤ 11
 11-11.5
 11.5-12
 12-13
 13-14
 14-15
 >15
Parity (number of full term pregnancies) parity Categorical
 nulliparous
 1 birth
 2 births
 3 births
 ≥ 4 births
Age at first birth (years) birth_dec Categorical
 ≤ 19
 19-22
 22-23
 23-25
 25-27
 27-30
 30-34
 34-38
 >38
Age at menopause (years) agemeno_dec Categorical
 ≤40
 40-45
 45-47
 47-48
 48-50
 50-51
 51-52
 52-53
 53-55
 >55
Height (meters) height_dec Categorical
 ≤ 1.55
 1.55-1.57
 1.57-1.60
 1.60-1.61
 1.61-1.63
 1.63-1.65
 1.65-1.66
 1.66-1.68
 1.68-1.71
 >1.71
Body mass index (BMI, kg/m2) bmi_dec Categorical
 ≤ 21.5
 21.5-23
 23-24.2
 24.2-25.3
 25.3-26.5
 26.5-27.8
 27.8-29.3
 29.3-31.4
 31.4-34.6
 >34.6
Use of Hormone Replacement Therapy (HRT) rd_menohrt Categorical
 Premenopausal
 Postmenopausal and never HRT user
 Postmenopausal and ever HRT user
Use of estrogen + progesterone combined therapy rd2_everhrt_c Binary
 Postmenopausal and ever user of combined therapy therapy
 Otherwise
Use of estrogen only therapy rd2_everhrt_e Binary
 Postmenopausal and ever user of estrogen only therapy
 Otherwise
Current use of HRT rd2_currhrt Binary
 Postmenopausal and current HRT user
 Otherwise
Alcohol, drinks/week alcoholdweek_dec Categorical
 None
 0-0.4
 0.4-0.8
 0.8-1.5
 1.5-3.2
 3.2-5.7
 5.7-9.8
 >9.8
Smoking status ever_smoke Binary
 Ever
 Never
Interaction of BMI and use of HRT rd_menohrt*bmi_dec Categorical